FIRST CLINICAL EXPERIENCE WITH FRACTIONATED INTRACAVITARY RADIOIMMUNOTHERAPY USING [177LU]LU-6A10-FAB FRAGMENTS IN PATIENTS WITH GLIOBLASTOMA: A PILOT STUDY

Abstract Background Following resection and standard adjuvant radio- and chemotherapy, approved maintenance therapies for glioblastoma are lacking.Intracavitary radioimmunotherapy (iRIT) with 177Lu-labeled 6A10-Fab fragments targeting tumor-associated carbonic anhydrase XII and injected into the resection cavity offers a novel and promising strateg

A micro-fiber-optic Fabry-Perot interferometer (FPI) is proposed and demonstrated experimentally for ultrasonic imaging of seismic physical models.The device consists of a micro-bubble followed by the end of a single-mode fiber (SMF).The micro-structure is formed by the discharging operation on a short segment of hollow-core fiber (HCF) that is spl

Landmark discoveries in pulley roller the gut microbiome field have paved the way for new research aimed at illuminating the influence of microbiota in colorectal cancer.A major challenge is to account for the effect of inherently variable environmental factors on the host and the gut microbiome, while concurrently determining their contribution to

Fire incidents occurring Axles onboard ships cause significant consequences that result in substantial effects.Fires on ships can have extensive and severe wide-ranging impacts on matters such as the safety of the crew, cargo, the environment, finances, reputation, etc.Therefore, timely detection of fires is essential for quick responses and powerf

The present article attempts at combining Big History potential with the Intermediate po-tential of Evolutionary Studies.It does not only analyze the history of the Cosmos.It studies similarities between evolutionary laws, principles, and mechanisms at various levels and phases of Big History.Such an approach opens up some new perspectives for our